Zoveelste studie die aantoont dat de PCR-test niet accuraat genoeg is om de maatregelen op te baseren. Zoals al de hele tijd het geval is, zwijgt de media hierover. Een nalatigheid die randje crimineel is.
Worldwide, detection and monitoring of SARS CoV-2 infection continues to be based on results of the real-time reverse-transcription polymerase chain reaction (RT-PCR) test. A recent scoping review in this journal reported that assessment of the diagnostic accuracy of the RT-PCR test for SARS-CoV-2 has been less than perfect . We analysed real-world data from a large laboratory in the city of Münster (population 313,000), Germany, derived from a single fully automated high throughput RT-PCR platform (cobas SARS-CoV-2 RT-PCR system, Roche Diagnostics) utilizing the same two gene targets for the entire study period (weeks 10-49, 2020). This laboratory performed about 80% of all SARS-CoV-2 RT-PCR tests in the Münster region during this time. We explored changes in the percentage of positive RT-PCR tests (positive rate) over time. In addition, we assessed the influence of covariates such as age, sex, calendar time, and symptoms at the time of first RT-PCR test on the distribution of cycle threshold (Ct) values.